Searchable abstracts of presentations at key conferences in endocrinology

ea0011p523 | Endocrine tumours and neoplasia | ECE2006

Glucocorticoid receptor gene N363S variant in patients with clinically inapparent adrenal adenomas

Reimondo G , Micossi I , Giachino D , Bovio S , Allasino B , Daffara F , Angeli A , Terzolo M , De Marchi M

N363S polymorphism of the human glucocorticoid receptor gene has been detected in the heterozygous state in approximately 3–9% of general European population. This variant has been associated with increased sensitivity to glicocorticoids, increased insulin response to dexamethasone, a tendency towards lower bone mineral density, increased body mass index, and unstable angina. However, other reports found no associations with these pathological conditions. We assessed the ...